Is Obesity-Related Risk for GI Cancers Sex-Dependent?
Is Obesity-Related Risk for GI Cancers Sex-Dependent?
9th Apr, 2022 09:44 PM
Cancer is the second leading cause of death worldwide, implementing major health care and socioeconomic burden. Overweight and obesity, both of which are dramatically on the rise in both high and less developed regions worldwide, have been established as modifiable risk factors for the development of various tumor entities including gastrointestinal (GI) cancers such as colorectal or gastric cancer.
Several gastrointestinal (GI) cancers (e.g. colorectal, gastric, esophagus, and liver cancer) are among the 10 most prevalent tumors worldwide in both sexes, and most have high morbidity and mortality. Primary prevention of cancer-based on established risk factors is a leading strategy to reduce the high number of cancer-associated deaths worldwide.
In addition to genetic alterations associated with increased risk for cancer development, several modifiable risk factors for cancer have been identified in recent decades. Among these, overweight and obesity, which are dramatically on the rise in both high and less developed regions worldwide, represent a crucial risk factor for cancer development. Although the underlying pathophysiological mechanism have not been fully elucidated today, several studies have proven an association between pre-obesity or obesity and an increased risk for cancer development for different cancer entities including post-menopausal breast cancer, cervix, and ovarian cancer, and renal cell carcinoma. Inline, there is a growing body of evidence suggesting an association between excessive body fat and the incidence of GI cancers such as colorectal cancer, gastric cancer, liver cancer, and pancreatic cancer.
Ukraine today
Ukraine today
5th Mar, 2022 12:35 PM

The health, wellbeing, and safety of the people of Ukraine have dominated the thoughts of many people this week, after Russia’s invasion of the country. Ethicist Julian Sheather reminds us how the impact of war ripples outwards, in space and time, through lives and generations. Reports of physical trauma and disruption to water, sanitation, and food are just the beginning of the harms to health. What can healthcare professionals do beyond managing the physical and mental aftermath of conflict? Gareth Iacobucci reports on an open, and moving, letter to Vladimir Putin signed by thousands of Russian doctors and healthcare workers urging him to cease hostilities against Ukraine..

Latest News 1
Latest News 1
25th Feb, 2022 04:00 PM
What are going to be the factors that influence who will win in the new age of electric mobility? The brands that will rule the road will be the ones that have access to the key ingredients that go into an EV. Legacy auto brands who haven’t been preparing themselves in time to deal with the transition are scrambling to ensure that they will have an assured supply of all key raw materials, including semi-conductors and batteries.